Rifabutin-Cobicistat Drug Interaction Resulting in Severe Bilateral Panuveitis
نویسندگان
چکیده
منابع مشابه
Differentiation of severe bilateral panuveitis following phacoemulsification: a case report
BACKGROUND Cataract surgery typically offers instant visual rehabilitation with rare postoperative complications. However, if complications occur, these complications may be confusing and threatening. We present a case of severe bilateral panuveitis following phacoemulsification and intraocular lens implantation and discuss the importance of a correct diagnosis and management. CASE PRESENTATI...
متن کاملSevere bilateral panuveitis during melanoma treatment by Dabrafenib and Trametinib
BACKGROUND We report a case of severe bilateral panuveitis during melanoma therapy with a combination of Dabrafenib, a B-raf (BRAF) inhibitor, and Trametinib, a mitogen/extracellular signal-regulated kinase (MEK) inhibitor. Both of these drugs are effectors in the mitogen-activated protein kinase (MAPK) pathway, which plays an important role in the physiopathology of melanoma. Dabrafenib and Tr...
متن کاملMelatonin Interaction Resulting in Severe Sedation.
PURPOSE Natural health products (NHPs), including melatonin, are widely used products. Despite the widespread assumption that all NHPs are safe, they contain pharmacologically active substances and can therefore have adverse effects and/or interact with pharmaceuticals. OBJECTIVE To investigate the mechanism underlying NHP interactions identified through the Pharmacy SONAR active surveillance...
متن کاملUpdate on rifampin and rifabutin drug interactions.
Rifampin is a potent inducer of cytochrome P-450 oxidative enzymes as well as the P-glycoprotein transport system. Several examples of well-documented clinically significant interactions include warfarin, oral contraceptives, cyclosporine, itraconazole, digoxin, verapamil, nifedipine, simvastatin, midazolam, and human immunodeficiency virus-related protease inhibitors. Rifabutin reduces serum c...
متن کاملSevere epilepsy resulting from genetic interaction between Scn2a and Kcnq2.
A mutation in the voltage-gated sodium-channel Scn2a results in moderate epilepsy in transgenic Scn2a(Q54) mice maintained on a C57BL/6J strain background. The onset of progressive epilepsy begins in adults with short-duration partial seizures that originate in the hippocampus. The underlying abnormality is an increase in persistent sodium current in hippocampal neurons. The voltage-gated potas...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Case Reports in Ophthalmology
سال: 2020
ISSN: 1663-2699
DOI: 10.1159/000506181